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The activity of lipoxygenases was highly sensitive to pH, with an optimum pH of 6.5, and it showed activity to pH within the range of 4.5 to 8.0 (Aanangi et al., 2023)

A decrease in intercellular lipids is present with a deficiency of all key lipids in the stratum corneum and an altered ratio of esterified fatty acids to ceramide, plus the persistence of corneodesmosomes and the premature expression of involucrin with cornified coat formation, resulting in marked corneocyte retention [110,126]